MHC – Major Histocompatibility Complex DP – Double Positive DN – Double Negative PBS – Phosphate-Buffered Saline SP – Single Positive CD – Cluster of Differentiation NK – Natural Killer cell TCR – T-Cell Receptor GPCR – G-Protein Coupled Receptor T-ALL – T-cell Acute Lymphoblastic Leukemia Cys - Cysteine AA – Amino Acid DMEM - Dulbecco's Modified Eagle's Medium CXCR4 – Chemokine CXC Receptor 4 N3-IC Tg – Notch3 Intracellular Transgenic (mice) ERK - Extracellular signal-Regulated Kinase SDF-1α – Stromal Derived Factor-1α CXCL12 – CXC Chemokine Ligand 12 NF-κB - Nuclear Factor Kappa-light-chain-enhancer of activated B cells WT – Wild-Type (mice) FACS – Fluorescence Activated Cell Sorting ECD – Extracellular Domain ICD – Intracellular Domain EGF – Epidermal Growth Factor HD – Heterodimerization Domain EpCAM – Epithelial Cell Adhesion Molecule ANK – Ankyrin Domain Bcl2-A1 - Bcl2-related protein A1