abject - utterly hopeless, miserable, humiliating, or wretched
acosmist - one who believes that nothing exists
agoraphobia - abnormal fear of being helpless in an embarrassing or unescapable situation that is characterized especially by the avoidance of open or public places
aloof - at a distance, especially in feeling or interest; apart
anoesis - a state of mind consisting of pure sensation or emotion without cognitive content.
anomie - a state or condition of individuals or society characterized by a breakdown or absence of social norms and values, as in the case of uprooted people.
asinine - foolish, unintelligent, or silly; stupid