For 05.01.19 (10.01.19 latest) Remember mechanism and experimental images

  • Antibiotics and antibiotic resistance
    • Add images
  • Nalidixic acid/quinolones and resistance
    • General quinolone info
    • How does bacterial mechanism work normally?
    • How do quinolones affect mechanism?
    • Action (DNA gyrase and topo IV)
    • Most common resistance mechanism
  • Genetic screen details
    • Show ydgJ growth on nal (compared to control)
    • How to reference unpublished?
  • ydgJ identification
    • Find as much general info as possible
    • From oxidoreductase genetics
    • Include homology model?
  • Oxidoreductases
    • Function
    • General info on different families
    • Conserved features/domains
    • Focus on one most homologous to ydgJ
    • How could they confer resistance?
    • Suggestion for ydgJ mechanism
  • State aim of project in context of background given
    • Interactome of ydgJ as showed resistance to nal in screen
    • Interacting proteins could give more info on how ydgJ resistance mechanism works
dec 10 2018 ∞
jan 7 2019 +