Note: the characters that’ll listed here are restricted to fully AU characters(or at least more AU than others here in Ani-Toonspiracy)

• Computer-Assisted and Biologically-Augmented lifeform: the reason is: his backstory is very different from his canon self(he’s uses different alien technology than his canon self) other than that, he’s still uses networks of (often) literal Human Brain in a Jar for his CPU(besides Monolith that makes this CABAL different from canon self)
• Frank Castle aka Punisher: his backstory is different from any of his (Canon) Marvel versions cuz he’s hails from Traverse Town instead of anywhere in Marvel Multiverse, his backstory is very similar to Punisher Kills the Marvel Universe self(in terms of being someone that loses his family to Superhuman battles, this time involves Warp-imbued C’Tan shard) where loss of his family drives him to join ACME corporation and got Batsuit-like nanosuit
• Lex Luthor and Hannibal Lecter: cuz of their flanderizations
• Silas from Da Vinci Code(since his universe are more AU than virtually everything else used in this mega-crossover)
• Deadpool: he hails from Earth-616-type Marvel Universe that canonically Unrelated to even main comics