I've seen a lot of these as movies, but I'm only counting the books I've read.

• Pride and Prejudice - Austen
• To Kill a Mockingbird - Lee
• Jane Eyre - Bronte
• Gone with the Wind - Mitchell
• Lord of the Rings - Tolkien
• The Catcher in the Rye - Salinger
• Little Women - Alcott
• A Prayer of Owen Meany - Irving
• The Stand - King
• The Great Gatsby - Fitzgerald
• Mists of Avalon - Bradley
• David Copperfield - Dickens
• Kristen Lavransdotter - Undset
• Beloved - Morrison
• Age of Innocence - Wharton
• The Shell Seekers - Pilcher
• Tess of the D'Urbervilles - Hardy
• The World According to Garp - Irving
• Catch 22 - Heller
• The Clan of the Cave Bear - Auel
• The Horse Whisperer - Evans
• Pillars of the Earth - Follett
• Prince of Tides - Conroy
• Possession - Byatt
• Rebecca - DuMaurier
• Follow the River - Thom
• My Antonia - Cather
• The Old Man and the Sea - Hemingway
• The Scarlet Letter - Hawthorne
• Sophies Choice - Styron
• Snow Falling on Cedars - Guterson
• One Hundred Years of Solitude - Marquez
• Name of the Rose - Eco
• The Giver - Lowry
• Cold Mountain - Frazier
• Cold Sassy Tree - Burns
• Atlas Shrugged - Rand
• Bridge to Terebithia - Paterson
• Dinner at the Homesick Restaurant - Tyler
• The Hobbit - Tolkien
• Les Miserables - Hugo
• The Lion, the Witch, and the Wardrobe - Lewis
• Wuthering Heights - Bronte
• A Tale of Two Cities - Dickens
• The Adventures of Huckelberry Finn - Twain
• Alice in Wonderland - Carroll
• The Wind in the Willows - Grahame
• The Bean Trees - Kingsolving
• Ben Hur - Wallace
• And Then There Were None - Christie
• The Secret Garden - Burnett
• Roll of Thunder, Hear My Cry - Taylor
• Busman's Honeymoon - Sayers
• Schindler's List - Keneally
• Emma - Austen
• The Color Purple - Walker
• The Count of Monte Cristo - Dumas
• Charlotte's Web - White
• Anne of Green Gables - Montgomery
• The Divine Secrets of the Ya-Ya Sisterhood - Wells
• Lady Chatterly's Lover - Lawrence
• A Tree Grows in Brooklyn - Smith
• East of Eden - Steinbeck
• The Once and Future King - White
• Enders Game - Card
• The Fountainhead - Rand
• A Patchwork Planet - Tyler
• Gaudy Night - Sayers
• Shogun - Clavell
• Grapes of Wrath - Steinbeck
• Handmaid's Tale - Atwood
• Lonesome Dove - McMurtry
• Outlander - Gabaldon
• Pigs in Heaven - Kingsolver
• Slaughterhouse-Five - Vonnegut
• Jude the Obscure - Hardy
• Time and Again - Finney
• Misery - King
• A Christmas Carol - Dickens
• The Accidental Tourist - Tyler
• Giants of the Earth - Rolvaag
• Persuasion - Austen
• Fried Green Tomatoes - Flagg
• Tisha - Specht
• The Thornbirds - McCullough
• Christy - Marshall
• Lost Horizon - Hilton
• The Little Prince - St. Exupery
• Fahrenheight 451 - Bradbury
• For Whom the Bell Tolls - Hemingway
• Frankenstein - Shelley
• Bleak House - Dickens
• Boy's Life - McCammon
• Chesapeake - Michener
• The Hitchhikers Guide to the Galaxy - Adams
• How Green Was My Valley - Llewellyn
• Howard's End - Forster
• I, Robot - Asimov
• Of Mice and Men - Steinbeck
• A Passage to India - Forster

from http://www.the-bookman.com/main/Best.books.html