- 1984 - A Nightmare on Elm Street - Glen Lantz
- 1985 - Private Resort - Jack Marshall
- 1986 - Slow Burn - Donnie Fleischer
- 1986 - Platoon - Lerner
- 1990 - Cry-Baby - Wade “Cry-Baby” Walker
- 1990 - Edward Scissorhands - Edward Scissorhands
- 1991 - Freddy’s Dead: The Final Nightmare - Guy on TV
- 1993 - Benny & Joon - Sam
- 1993 - What’s Eating Gilbert Grape - Gilbert Grape
- 1993 - Arizona Dream - Axel Blackmar
- 1994 - Ed Wood - Edward D. Wood, Jr.
- 1995 - Don Juan DeMarco - Don Juan/John R. DeMarco
- 1995 - Dead Man - William Blake
- 1995 - Nick of Time - Gene Watson
- 1997 - Donnie Brasco - Donnie Brasco/Joseph D. Pistone
- 1997 - The Brave - Raphael
- 1998 - Fear and Loathing in Las Vegas - Raoul Duke
- 1998 - L.A. Without a Map - Himself/William Blake
- 1999 - The Ninth Gate - Dean Corso
- 1999 - Sleepy Hollow - Ichabod Crane
- 1999 - The Astronaut’s Wife - Spencer Armacost
- 2000 - Chocolat - Roux
- 2000 - Before Night Falls - Lt. Victor, Bon Bon
- 2001 - Blow - George Jung
- 2001 - The Man Who Cried - Cesar
- 2001 - From Hell - Frederick Abberline
- 2003 - Once Upon a Time in Mexico - Sheldon Sands
- 2003 - Pirates of the Caribbean: The Curse of the Black Pearl - Captain Jack Sparrow
- 2004 - Happily Ever After - L’inconnu
- 2004 - Secret Window - Mort Rainey
- 2004 - Finding Neverland - J. M. Barrie
- 2004 - The Libertine - John Wilmot, 2nd Earl of Rochester
- 2005 - Charlie and the Chocolate Factory - Willy Wonka
- 2005 - Corpse Bride - Victor Van Dort (voice)
- 2006 - Pirates of the Caribbean: Dead Man’s Chest - Captain Jack Sparrow
- 2007 - Pirates of the Caribbean: At World’s End - Captain Jack Sparrow
- 2007 - Sweeney Todd: The Demon Barber of Fleet Street - Sweeney Todd/Benjamin Barker
- 2009 - Public Enemies - John Dillinger
- 2009 - The Imaginarium of Doctor Parnassus - Tony
- 2010 - Alice in Wonderland - Mad Hatter
- 2010 - The Tourist - Frank Tupelo/Alexander Pearce
- 2011 - Rango - Rango (voice)
- 2011 - Pirates of the Caribbean: On Stranger Tides - Captain Jack Sparrow
- 2011 - The Rum Diary - Paul Kemp
- 2011 - Jack and Jill - Himself
- 2012 - 21 Jump Street - Thomas “Tom” Hanson, Jr., DEA
- 2012 - Dark Shadows - Barnabas Collins
- 2013 - The Lone Ranger - Tonto
- 2013 - Lucky Them - Matthew Smith
- 2014 - Transcendence - Dr. Will Caster
- 2014 - Tusk - Guy Lapointe
- 2014 - Into the Woods - The Wolf
- 2015 - Mortdecai - Charles Mortdecai
- 2015 - Black Mass - Whitey Bulger
- 2015 - London Fields - Mark Asprey
- 2015 - Yoga Hosers - Guy Lapointe
- 2016 - Alice in Wonderland: Through the Looking Glass - Mad Hatter
- 2017 - Pirates of the Caribbean: Dead Men Tell No Tales - Captain Jack Sparrow
feb 4 2016 ∞
oct 22 2016 +