In no particular order.

• Global warming and the slow, human-caused deterioration of our planet
• The genocide in Darfur and the fact that we (as in the United States) are not doing anything to stop it
• The fact that there are ridiculously wealthy people in the world who could literally live off their interest while there are people who don't have enough food to eat.
• The fact that people don't read as much as they used to. People have become dependent on television and the internet to entertain them, and find reading boring.
• Endangered species
• Intolerance of people with different sexual preferences
• Discrimination of any kind
• The power of big media
• Materialism and consumerism
• The pitiful state of our country's education system and the fact that free education ends at a point when you are not able to get a job that will support a family